| 摘要 |
<p>The invention provides assays for identifying a receptor modulator wherein a transferable label is contacted with a candidate receptor modulator, a fusion protein comprising a viral receptor binding moiety and a ligand, and a target cell that expresses a cell surface-ligand-receptor. Alternatively, a virus particle comprising a mutant envelope protein, wherein the virus particle can bind to a viral receptor but demonstrates impaired entry into a cell, and further comprising a transferable label is contacted with a fusion protein comprising a viral receptor binding moiety and a ligand, and a target cell that expresses a cell surface receptor capable of binding to the ligand of the fusion protein. Binding of the fusion protein to a virus receptor on the target cell inhibits or activates transfer of the transferable label from the virus particle to the cell.</p> |
