| 摘要 |
<p>A process is described for the stereospecific preparation of an ester of formula (I): wherein *signifies the (R) stereoisomer; R1 is selected from C1 -6 alkyl, preferably ethyl; and R2 is hydrogen, a protecting group or a leaving group which process comprises reaction of a nitrile of formula (II): wherein *signifies the (R) stereoisomer; and Ph is the phenyl group C6 H5 with a solution of an inorganic acid in an alcohol and optional conversion of the compound of formula (I) wherein R2 is H so prepared to any other desired compound of formula (I) by standard methods in the art. The compounds of formula (I) are chiral esters, useful as intermediates in the synthesis of t he family of acetylcholine esterase (ACE) inhibitors known as 'prils', such as lisinopril, cilazapril, enalapril, benazepril, ramipril, delapril, enalaprilat, imidapril, spirapril, trandolapril and others.</p> |
