| 摘要 |
Animal feeds comprising a compound that disrupts the peptidoglycan layer of bacteria and a compound that disrupts the phospholipid layer of bacteria are disclosed. The feed is particuarly active against Gram negative bacteria which possess both a lipopolysaccharide/lipid outer layer, and an inner peptidoglycan layer. The compounds can act synergistically against bacteria, and therefore improve the growth or the feed conversion ratio of animals. The feed may be fed to monogastric and/or non-ruminant animals such as poultry, pigs, piglets, (veal) calves or fish. The phospholipid disrupting compound can be a phospholipase, polyunsaturated fatty acid (PUFA, such as arachidonic acid) or a chelating agent (such as EDTA). The peptidoglycan disrupting layer can be an enzyme, such as an endoglycosidase or a peptidase, that can either hydrolyse peptidoglycan or cleave peptide crosslinks. The enzyme is preferably lysozyme. |
