Process for the preparation of antihistaminic 4-diphenylmethyl piperidine derivatives
摘要
<p>The present invention is related to processes for the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0. <CHEM></p>
申请公布号
EP1260504(A1)
申请公布日期
2002.11.27
申请号
EP20020012626
申请日期
1994.05.26
申请人
MERRELL PHARMACEUTICALS INC.
发明人
KRAUSS, RICHARD C.;STROM, ROBERT M.;SCORTICHINI, CAREY L.;KRUPER, WILLIAM J.;WOLF, RICHARD, A.;CARR, ALBERT, A.;RUDISILL, DUANE, E.;PANZONE, GIANBATTISTA;HAY, DAVID, A.;WU, WEISHI, W.