METHOD OF PRODUCTION FOR gem-DIFLUORO COMPOUND

摘要

PROBLEM TO BE SOLVED: To provide a method synthesizing a gem-difluoro compound having the objective gem-difluoro structure from an easily obtainable carbonyl compound in high yield. SOLUTION: This method produces the compound expressed by formula (2) in a selective ratio >=98% by reacting a compound expressed by formula (1) and a fluorinating agent in the presence of a Lewis acid catalyst. The selective ratio is defined as a ratio of the mass of the compound expressed by formula (2) to the total mass of the compound expressed by formula (2) and a compound expressed by formula (3). R<1> , R<2> and R<3> are each a monovalent group. Two groups selected from R<1> , R<2> and R<3> optionally form a bivalent organic group and the rest is a monovalent group.