FLUORINATING AGENT AND METHOD FOR PRODUCING 1-ALKOXY-2- FLUORO-3-HYDROXY COMPOUND BY NUCLEOPHILIC RING-OPENING FLUORINATION TO 1-ALKOXY-2, 3-EPOXY COMPOUND

摘要

PROBLEM TO BE SOLVED: To obtain a fluorinating agent for promoting a selective fluorination at C-2 position in a ring-opening fluorination of a 1-alkoxy-2, 3-epoxy compound and provide a method for producing a 1-alkoxy-2-fluoro-3-hydroxy compound by nucleophilic ring-opening fluorination. SOLUTION: A selective ring-opening fluorination of a 1-alkoxy-2, 3-epoxy compound is promoted and a selectively fluorinated product at C-2 position is produced by using a fluorinating agent consisting of ammonium fluoride and a metal fluoride of the forth family.