BIOSTIMULATING MATERIAL DERIVED FROM ACTINOMYCES, EXTRACTING METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PURPOSE: Provided are a biostimulating material derived from Actinomyces, an extracting method thereof and a pharmaceutical composition containing the same. The biostimulating material has toxicity to various cancer cells, so that it can be useful as an anticancer drug. CONSTITUTION: The biostimulating material derived from Actinomyces is represented by formula(1), in which R1 and R2 are the same or different, and hydrogen, methyl, ethyl, propyl or isopropyl. The method for extracting the biostimulating material derived from Actinomyces comprises the steps of: culturing Streptomyces sp. in a broth; filtering the cultured medium to isolate a mycelium; extracting the mycelium with at least one of methanol, ethanol, chloroform, acetone and dichloromethane; evaporating the crude extract solution under reduced pressure to obtain a residue; fractionating the residue according to its polarity; evaporating a polar fraction under reduced pressure to obtain a polar organic concentrate; and subjecting the polar organic concentrate to chromatography.