PRACTICAL SYNTHETIC METHOD OF RETINOID AND CAROTENOID COMPOUNDS

摘要

The present invention relates to an effective and practical method for preparing retinol (Chemical Formula 2), retinal (Chemical Formula 3) and beta carotene (Chemical Formula 4) by using C-15 allylic disulfone compound (Chemical Formula 1) as an intermediate compound, that is prepared through a stable and economic process, for syntheses of retinoid and carotenoid compounds.According to the present invention, retinol (Chemical Formula 2), retinal (Chemical Formula 3) and beta -carotene (Chemical Formula 4) are effectively prepared, via coupling reaction of carbanion that is obtained from deprotonation of the C-15 disulfone compound (Chemical Formula 1) by excess amount (2 equivalents or more) of base, with C-5 halo-acetate compound (A), C-5 halo-acetal compound (C) and C-10 dihaloallylic sulfide compound (F), respectively followed by dehydrosulfonation reaction.