MICROFLUIDIC SYSTEM FOR THE MANIPULATION AND CONCENTRATION OF PARTICLES SUSPENDED IN LIQUID
摘要
A microfluidic system for the concentration of particulate matter comprises a first reservoir (1) containing a buffer solution, a second reservoir (2) containing a analyte, and a third reservoir (3) containing beads suspended in a liquid. Microchannels link the reservoirs and an expanded portion (4). Hydrostatic pressure is applied to the reservoir (3) containing the beads while an electro-osmotic force (EOF) is applied between the reservoir (1) and the reservoir (3) to establish counter flows of liquids. A vortex forms in the flared portion (5) due to the counter flow of the liquids and the beads are concentrated in the vortex. By switching the EOF between reservoirs (1) and (2) the buffer solution can be replaced by the analyte to enable an analysis to be performed.
申请公布号
WO02092222(A2)
申请公布日期
2002.11.21
申请号
WO2002EP05324
申请日期
2002.05.13
申请人
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE S.A.;BOER, GERBEN;DODGE, ARASH;LETTIERI, GIANLUCA;VERPOORTE, ELISABETH
发明人
BOER, GERBEN;DODGE, ARASH;LETTIERI, GIANLUCA;VERPOORTE, ELISABETH