发明名称 |
ENTSPERRUNG DES GEMEINSAMEN SYNTHESEWEGES VON AROMATISCHEN AMINOSÄUREN |
摘要 |
Enhanced efficiency of production of aromatic compounds via the common pathway, as shown in the figure, of a host cell is realized by increasing the expression of enzyme species acting on substrate intermediates in identified rate-limiting reaction steps in the pathway. Host cells are transformed with recombinant DNA encoding for the rate-limiting enzymes to provide cell transformants characterized by capacity to produce high concentrations of aromatic metabolites when grown in cell culture with a metabolizable carbon source. |
申请公布号 |
DE69331707(T2) |
申请公布日期 |
2002.11.21 |
申请号 |
DE1993631707T |
申请日期 |
1993.12.09 |
申请人 |
PURDUE RESEARCH FOUNDATION, WEST LAFAYETTE;GENENCOR INTERNATIONAL, INC. |
发明人 |
FROST, W.;DELL, A.;DRATHS, M.;BERRY, ALAN |
分类号 |
C12N15/09;C12N1/21;C12N9/10;C12N9/12;C12N9/88;C12N15/22;C12N15/52;C12P13/04;C12P13/22;C12R1/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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