4−(4−PYRIDAZINYL)PYRAZOLE DERIVATIVES

摘要

4−(4−Pyridazinyl)pyrazole derivatives represented by the following general formula or salts thereof have an excellent p38MAP kinase inhibitory activity, which makes them useful in preventing or treating tumor necrosis factor−&agr;−associated diseases, interleukin−1−associated diseases, interleukin−6−associated diseases or cyclooxygenase II−associated diseases: (I) wherein Q represented optionally substituted aryl, etc.; R1 represents hydrogen, halogeno, etc.; R2 represents hydrogen, lower alkyl, etc.; and R3 represents hydrogen, −CH2−CH(R4)−(A)n−Y (wherein A represents lower alkylene; Y represents optionally substituted aryl; R4 represents hydrogen or lower alkyl; and n is 0 or 1), etc.