| 摘要 |
The invention provides isolated nucleic acid molecules, designated 66784 nucleic acid molecules, which encode novel potassium channel family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 66784 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 66784 gene has been introduced or disrupted. The invention still further provides isolated 66784 proteins, fusion proteins, antigenic peptides and anti-66784 antibodies. The present invention also relates to methods for the diagnosis and treatment of metabolic disease, including, but not limited to, obesity, diabetes, anorexia, and cachexia. The present invention describes methods for the diagnostic evaluation and prognosis of various metabolic diseases. The invention also provides methods for identifying a compound capable of modulating metabolic disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of metabolic disease.
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