NONHUMAN MODEL ANIMAL OF OLIGODENDROCYTE DEVELOPMENT DISABILITY

摘要

The mechanism causing psychoneurotic disorders such as Nasu-Hakora disease is analyzed to thereby provide a method of preventing the progress of the psychoneurotic disorders, remedies for the psychoneurotic disorders, a method of screening the same and a therapeutic method. A nonhuman model animal of oligodendrocyte development disability is constructed by deleting the DAP12 gene function on chromosome. The DAP12-knockout mouse suffers from hypomyelination in the brain (in particular, forehead and thalamus), namely, myelinization disorders including hypomyelination. As aging proceeds, this animal further suffers from psychoneurotic disorders such as Nasu-Hakora disease. Using the DAP12-knockout mouse showing these disorders, a method of screening a remedy, a diagnostic method and a therapeutic method are developed.