ABUSE-RESISTANT CONTROLLED-RELEASE OPIOID DOSAGE FORM

摘要

Abuse-resistant, controlled release opioid tablets in combination containing an opioid antagonist such as naloxone at a level above that needed to suppre ss the euphoric effect of the opioid, if the combination were crushed to break the controlled release properties causing the opioid and opioid antagonist t o be released as a immediate release product as a single dose. The controlled release nature of the table prevents the accumulation of orally effective amounts of opioid antagonist when taken normally. The opioid antagonist is contained in a controlled-release matrix and released, over time, with the opioid.