SYSTEM FOR DISCOVERY OF AGENTS THAT BLOCK <i>YERSINIA PESTIS</i> AND <i>PSEUDOMONAS AERUGINOSA</i> DNA REPLICATION

摘要

Y. pestis and P. aeruginosa nucleic acid molecules encoding dnaE, holA, holB, holC, holD, holE, dnaX, dnaN, SSB, dnaG, dnaQ, proteins are provided. The encoded proteins are also provided. The nucleic acid molecules and proteins are useful for reconstituting replicases and polymerases for sequencing, amplification, and screening for compounds which modulate the function of the polyemersase or replicase.