METHOD OF TREATING AMYLOID < PRECURSOR DISORDER

摘要

Methods for the treatment and prevention of APP processing disorders such as Alzheimer's disease and Down's Syndrome which are based on the administration of an effective amount of a HMG-CoA reductase inhibitor to a mammal are disclosed. Additionally, methods for treatment and prevention of APP processing disorders such as Alzheimer's disease and Down's Syndrome which are based on the reduction of cellular cholesterol in a mammal are disclosed. These methods reduce the amount of AB peptides or decrease the formation of AB peptides or increase the clearance of AB peptides in a mammal suffering from Alzheimer's disease and Down's Syndrome. Figure (1) is a schematic which illustrates APP processing.