17-(C(CH3) (CH2) O-3C (R4, R5) N (R6, R7))-SUBSTITUTED 19-NOR-PREGNA-1, 3, 5(10)-TRIENE DERIVATIVES AND THEIR MEDICAL USE

摘要

Compounds of formula (I) in which: R<1> represents a hydrogen atom or an o-protecting group; R<2> represents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower alkoxy-substituted lower alkyl group; R<3> represents a methyl group having alpha - or beta - configuration; X represents a C1-3 alkylene group or a valence bond; Y represents a group of formula -C(R<4>) (R<5>)NR<6>R<7> where R<4> and R<5>, which may be the same or different, are each selected from hydrogen atoms, alkyl, alkenyl and alkynyl groups such that the total carbon content of R<4> and R<5> does not exceed three atoms; R<6> represents a hydrogen atom, an aliphatic or araliphatic organic group, or an acyl group comprising an aliphatic, araliphatic or aryl organic group linked to the nitrogen atom by way of a carbonyl group; and R<7> is a hydrogen atom or a lower alkyl group; and the dotted line signifies that a double bond may optionally be present at the 16(17)-position exhibit potent cell modulating activity, including antiproliferative and antiangiogenic effects.