FUSED IMIDAZOLIDINE DERIVATIVES, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF

摘要

Compounds represented by the general formula (I) and having excellent inhibitory activity against the degradation of cartilage matrix; or salts or sulfoxides of the same: (I) wherein R1 is -(S)n-R2 (wherein R2 is optionally substituted hydrocarbyl or the like; and n is an integer of 0 to 2) or the like; R5 is hydrogen, optionally substituted hydrocarbyl, or the like; symbol (II) is a group represented by the general formula (III) or the like; and symbol (IV) is a group represented by the general formula (V) or the like: (II) (III) (IV) (V) [wherein R6 is hydrogen, optionally substituted hydrocarbyl, or the like; R10 is -ZR15 (wherein Z is -SO2- or the like; and R15 is optionally substituted hydrocarbyl or the like) or the like; and R11 is hydrogen or the like].