| 摘要 |
Compounds represented by the following general formula (I), prodrugs thereof , salts thereof and drugs containing the same as the active ingredient: (I) wherein each symbol has the meaning as defined in the specification. Because of having an EDG-1 agonism, the compounds of the general formula (I) are useful in preventing and/or treating arteriosclerosis obliterans, thromboangiitis obliterans, Buerger~s disease, peripheral arterial disease o f diabetic neuropathy, sepsis, angiitis, nephritis, pneumonia, brain infarctio n, myocardial infarction, edematous diseases, arteriosclerosis, hemorrhoid, ana l fissure, varicosity such as anal fistula, dissecting aneurysm, angina, DIC, pleuritis, congestive heart failure, multiorgan failure, bedsore, ambustion, ulcerative colitis, Crohn~s disease, heart transplantation, kidney transplantation, skin transplantation, liver transplantation, osteoporosis, pulmonary fibrosis, interstitial pneumonia, chronic hepatitis, cirrhosis, chronic renal failure or glomerular sclerosis.
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