| 摘要 |
<p>Growth hormone (GH) in which the regulated secretory pathway (RSP) sorting signal has been mutated as well as GH in which the three-dimensional conformation of the RSP sorting signal has been altered is disclosed. The mutated GH can be included in a composition and the mutated GH can be produced recombinantly. The mutation of GH results in GH which can be constitutively secreated by the nonregulated secretory pathway (NRSP) in a mmalian cell.</p> |
