发明名称 |
MHC-I-restricted presentation of HIV-1 virion antigens without viral replication. Application to the stimulation of CTL and vaccination in vivo; analysis of vaccinating composition in vitro |
摘要 |
Dendritic cells and macrophages can process extracellular antigens for presentation by MHC-I molecules. HIV-1 epitopes derived from incoming virions are presented through the exogenous MHC-I pathway in primary human dendritic cells, and to a lower extent in macrophages, leading to cytotoxic T lymphocyte activation in the absence of viral protein neosynthesis. Exogenous antigen presentation required adequate virus-receptor interactions and fusion of viral and cellular membranes. These results provide new insights about how anti-HIV cytotoxic T lymphocytes can be activated and are useful for anti-HIV vaccine design.
|
申请公布号 |
US2002172683(A1) |
申请公布日期 |
2002.11.21 |
申请号 |
US20020083678 |
申请日期 |
2002.02.27 |
申请人 |
SCHWARTZ OLIVIER;BUSEYNE FLORENCE;MARSAC DELPHINE;MICHEL MARIE-LOUISE;RIVIERE YVES;HEARD JEAN-MICHEL |
发明人 |
SCHWARTZ OLIVIER;BUSEYNE FLORENCE;MARSAC DELPHINE;MICHEL MARIE-LOUISE;RIVIERE YVES;HEARD JEAN-MICHEL |
分类号 |
A01N63/00;A61K39/21;A61K48/00;C07H21/04;C07K14/16;C12N7/04;C12N15/09;C12N15/63;C12N15/70;C12N15/74;C12Q1/68;C12Q1/70;G01N33/50;G01N33/567;(IPC1-7):A61K39/12;C12N7/00;C12N15/86 |
主分类号 |
A01N63/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|