A method of diagnosing cancer in a human patient comprising the steps of (i) obtaining a sample containing nucleic acid and/or protein from the patient; and (ii) determining whether the sample contains a level of hNeNa voltage-gated Na<+> channel nucleic acid or protein associated with cancer. A method of treating cancer comprising the step of administering to the patient an agent which selectively prevents the function of hNe-Na voltage-gated Na<+> channel. A genetic construct comprising a nucleic acid encoding a molecule capable of preventing the function of hNeNa voltage-gated Na<+> channel expressed in a cell. The methods and compositions are particularly suited to prostate cancer.
申请公布号
WO0218637(A3)
申请公布日期
2002.11.21
申请号
WO2001GB03940
申请日期
2001.09.03
申请人
IMPERIAL COLLEGE INNOVATIONS LIMITED;DJAMGOZ, MUSTAFA, BILGIN, ALI;FRASER, SCOTT, PATON;DISS, JAMES, KENNETH, JOSEPH
发明人
DJAMGOZ, MUSTAFA, BILGIN, ALI;FRASER, SCOTT, PATON;DISS, JAMES, KENNETH, JOSEPH