发明名称 |
KINETIC ASSAY |
摘要 |
A hapten-linker-large group conjugate for use in a rapid assay, wherein the assay is kinetic-based not approaching equilibrium, the hapten-linker-large group conjugate being of the general formula: X - W - Y - Zwherein:X is a hapten;W is an optional thioether or ether group;Y is a linker of 10 or more atoms in length; andZ is a large group of sufficient size to provide steric hindrance with respect to the binding of X to a ligand in the absence of Y.Also provided are processes for the production of the conjugates, assay methods and kits. The assays of the invention utilising conjugates of the invention [(5)-OVA] provide a better sensitivity than the same assays with conjugates with shorter linkers [(2)-OVA and 3-OVA].
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申请公布号 |
CA2447032(A1) |
申请公布日期 |
2002.11.21 |
申请号 |
CA20022447032 |
申请日期 |
2002.05.14 |
申请人 |
THE HORTICULTURE AND FOOD RESEARCH INSTITUT OF NEW ZEALAND LIMITED |
发明人 |
WU, YINQIU;COOK, CHRISTIAN JOHN;MITCHELL, JOHN STANTON |
分类号 |
G01N33/53;C07J33/00;C07J43/00;C07K14/76;G01N33/531;G01N33/543;(IPC1-7):C07K14/77;G01N33/72 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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