| 摘要 |
FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to novel sulfonylaminocarboxylic acids of the formula: and/or their stereoisomeric forms and/or physiologically acceptable salts where R1 means phenyl or phenyl mono- or disubstituted with group C1-C6-alkyl-O, halogen atom, trifluoromethyl group, group C1-C6-alkyl-O-C(O)-, methylenedioxy-group, R4-(R5)N-; triazole, thiophene, pyridine; R2 means H, C1-C6-alkyl; R4 and R5 are similar of different and mean H, C1-C6-alkyl; R3 means H, C1-C10-alkyl where alkyl is unsubstituted and/or one hydrogen atom of alkyl residue is substituted with hydroxyl-group; C2-C10-alkenyl; R2 means -S(O)n-C1-C6-alkyl where n = 0, 1, 2; R2 means S(O)(=NH)-(C1-C6)-alkyl and others; or R2 and R3 form in common cycle with carboxyl group as substitute of cycle of partial formula (II): where r = 0, 1, 2, 3 and/or one of carbon atom in cycle is substituted with +O-; and/or carbon atom in cycle of partial formula (II) is substituted with phenyl once; A means covalent bond, -O-; B means (CH2)m where m = 0; X means +CH=CH- or S. Compounds of the formula (I) are strong inhibitors of matrix metalloproteinases. Compounds of the formula (I) are synthesized from compound of similar structure that has where means R8-alkyl, phenyl instead C1-C6. EFFECT: valuable biochemical properties of compounds. 4 cl, 2 tbl, 3 ex
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