Mikrosf¶rer med forsinket frigjöring for injeserbar administrering og fremgangsmåte til fremstilling derav

摘要

The subject of the present invention is microspheres intended to be administered by injection, comprising a protein active ingredient and an agent coating the active ingredient intended to prolong its release, free of any trace of organic solvent and obtainable according to a coating method involving bringing the active ingredient and the coating agent into contact, with stirring, in a supercritical fluid, the said coating agent being soluble in the supercritical fluid. The protein active ingredient is not denatured.