发明名称 |
Membrane-bound cytokine compositions comprising GM-CSF or an active fragment thereof and methods of modulating and an immune response using the same |
摘要 |
The present invention provides a cellular vaccine having a membrane-bound fusion protein that includes a non-antibody immunomodulatory molecule operatively fused to a heterologous membrane attachment domain. Non-antibody immunomodulatory molecules useful in the invention include immunostimulatory and immunosuppressive molecules such as cytokines. In one embodiment, the invention provides a cellular vaccine having a membrane-bound fusion protein that includes a non-antibody immunomodulatory molecule operatively fused to a heterologous membrane attachment domain and, additionally, a disease-associated antigen or immunogenic epitope thereof. Further provided by the invention are methods of modulating an immune response against a disease-associated antigen by administering to an individual a cellular vaccine having a membrane-bound fusion protein that includes a non-antibody immunomodulatory molecule operatively fused to a heterologous membrane attachment domain.
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申请公布号 |
US6482407(B2) |
申请公布日期 |
2002.11.19 |
申请号 |
US20010847185 |
申请日期 |
2001.05.01 |
申请人 |
THE IMMUNE RESPONSE CORPORATION |
发明人 |
SOO HOO WILLIAM |
分类号 |
C12N15/09;A61K35/12;A61K35/66;A61K39/00;A61K39/39;A61K48/00;A61P35/00;A61P37/02;C07K14/475;C07K14/52;C07K14/535;C07K14/705;C07K14/71;(IPC1-7):A61K39/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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