4,5-dihydro-1H-pyrazolderivater med CB1-antagonist aktivitet

摘要

The present invention relates, among many things, to novel 4,5-dihydro-1H-pyrazole compounds which can be potent antagonists of the cannabis CB1-receptor.The compounds have the formula (I)whereinR and R1 are the same or different and represent unsubstituted or substituted phenyl, thienyl, or pyridyl, or naphthyl. naphthylR2 represents hydrogen, hydroxy, C1-3-alkoxy, acetyloxy or propionyloxy,Aa represents one of the groups (i), (ii), (iii), (iv) or (v) as defined herein,Bb represents sulfonyl or carbonyl, andR3 represents benzyl, phenyl, thienyl or pyridyl, each of which is unsubstituted or substituted, or R3 represents C1-8 branched or unbranched alkyl or C3-8 cycloalkyl, or R3 represents naphthyl.