发明名称 |
Production method of aromatic carboxylic acid derivative |
摘要 |
The present invention provides methods for producing a highly pure aromatic bromocarboxylic acid derivative and an aromatic acylthiocarboxylic acid derivative in high yields. The methods of the present invention include reacting an aromatic amino acid in an aqueous solvent in the presence of sodium nitrite, hydrogen bromide and at least one member selected from the group consisting of an aliphatic carboxylic acid and an alcohol, to give an aromatic bromocarboxylic acid derivative, and reacting the aromatic bromocarboxylic acid derivative and an organic thio acid in the presence of an amine to give an aromatic acylthiocarboxylic acid derivative.
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申请公布号 |
US6482978(B2) |
申请公布日期 |
2002.11.19 |
申请号 |
US20010820009 |
申请日期 |
2001.03.29 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
TAKAHASHI DAISUKE;NAKAZAWA MASAKAZU;IZAWA KUNISUKE |
分类号 |
C07C323/64;C07C51/363;C07C327/32;(IPC1-7):C07C321/00;C07C323/00;C07C325/00;C07C335/00;C07C381/00 |
主分类号 |
C07C323/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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