Methods for treating cancer

摘要

Dendritic cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer and autoimmune disease, by facilitating the migration or activation of antigen-presenting dendritic cells. In particular, methods are provided for treating cancer in a mammal comprising administering to said mammal an effective amount of a targeting construct comprising 6Ckine or a biologically active fragment or variant thereof and a targeting moiety.