| 发明名称 |
GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO |
| 摘要 |
GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3a</SUB>, R<SUB>3b</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB>, R<SUB>6 </SUB>and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof. |
| 申请公布号 |
EP1255738(A2) |
申请公布日期 |
2002.11.13 |
| 申请号 |
EP20010910362 |
申请日期 |
2001.01.25 |
| 申请人 |
NEUROCRINE BIOSCIENCES, INC. |
发明人 |
ZHU, YUN-FEI;CHEN, CHEN;TUCCI, FABIO, C.;GUO, ZHIQIANG;GROSS, TIMOTHY, D.;ROWBOTTOM, MARTIN;STRUTHERS, R., SCOTT |
| 分类号 |
C07D239/52;C07D239/54;A61K31/513;A61K31/5377;A61K31/5383;A61K31/55;A61P1/04;A61P5/24;A61P13/08;A61P15/00;A61P15/18;A61P25/20;A61P35/00;A61P37/06;C07D239/553;C07D401/04;C07D401/06;C07D401/12;C07D401/14;C07D403/04;C07D403/06;C07D403/12;C07D405/04;C07D405/12;C07D405/14;C07D409/04;C07D409/12;C07D409/14;C07D413/04;C07D413/06;C07D413/14;C07D417/04;C07D471/04;C07D487/04;C07D491/08;C07D498/18;C07D513/04;(IPC1-7):C07D239/00 |
主分类号 |
C07D239/52 |
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