发明名称 |
METHODS FOR DETECTING, IDENTIFYING, ISOLATING, AND SELECTIVELY LABELLING AND TARGETING TH1 LYMPHOCYTES BY MEANS OF THE LAG-3 PROTEIN |
摘要 |
<p>The lymphocyte ativation gene (LAG-3) is a member of the immunoglobulin superfamily that is selectively transcribed in human activated T and NK cells. Surface LAG-3 expression correlated with IFN-gamma but not IL-4, production in antigen-stimulated T-cells and it was up-regulated by IL-12 and is preferentially associated with CD4+ T-cells producing Th1-type cytokines. The presence of LAG-3 on the surface of Th1 lymphocytes is used as a marker to detect and identify Th1 lymphocytes and differentiate them from Th2 lymphocytes. Monoclonal antibodies to LAG-3 are used in methods of detecting and isolating Th1 cells as well as methods of diagnosing Th1-mediated disease. The present invention also relates to methods of treating infectious diseases, cancer, and disorders assocated with Th1/Th2 imbalance.</p> |
申请公布号 |
EP0843557(B1) |
申请公布日期 |
2002.11.13 |
申请号 |
EP19960926748 |
申请日期 |
1996.07.19 |
申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);INSTITUT GUSTAVE ROUSSY |
发明人 |
ROMAGNANI, S. |
分类号 |
C12N15/09;A01N1/02;A01N63/00;A61K31/00;A61K35/26;A61K35/66;A61K38/00;A61K39/395;A61K45/00;A61P31/00;A61P35/00;A61P37/00;B01D15/08;B01D43/00;B01D57/00;B03C1/00;C07K14/705;C07K16/00;C07K16/28;C12N5/00;C12N5/0783;C12N15/02;C12P21/08;G01N33/53;G01N33/536;G01N33/553;G01N33/569;(IPC1-7):A61K39/395;C12N5/08;C12N5/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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