发明名称 |
Substrate for detection of mammalian 5-C-DNA methyltransferase |
摘要 |
A substrate selective for detection of mammalian 5-C-DNA methyltransferase in the presence of bacterial 5-C-DNA methyltransferase, said substrate comprising oligomeric DNA which contains at least one 5-methylcytosine residue, and at least one cytosine or 5-fluorocytosine residue, each of which are followed in linkage to a guanine residue. The invention also includes a method for measuring the presence of mammalian 5-C-DNA methyltransferase which comprises contacting a sample containing 5-C-DNA methyl transferase with the substrate and also includes a method for inhibiting mammalian 5-C-DNA methyltransferase which comprises contacting a sample containing 5-C-DNA methyl transferase with the substrate. |
申请公布号 |
EP0756008(B1) |
申请公布日期 |
2002.11.13 |
申请号 |
EP19960111226 |
申请日期 |
1996.07.12 |
申请人 |
HEALTH RESEARCH, INC.;CHRISTMAN, JUDITH K.;SHEIKHNEJAD, GHOLAMREZA |
发明人 |
SUFRIN, JANICE R.;CHRISTMAN, JUDITH K.;MARASCO, CANIO JR.;SHEIKHNEJAD, GHOLAMREZA |
分类号 |
C12N15/09;A61K31/70;A61P35/00;C07H21/04;C12Q1/48;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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