发明名称 Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidaemia and hyperuricaemia
摘要 <p>Use of the (-) stereoisomer of a compound of Formula I, wherein: R is a member selected from the group consisting of a hydroxy, lower aralkoxy, di-lower alkylamino-lower alkoxy, lower alkanamido lower alkoxy, benzamido-lower alkoxy, ureido-lower alkoxy, N'-lower alkyl-ureido-lower alkoxy, carbamoyl-lower alkoxy, halophenoxy substituted lower alkoxy, carbamoyl substituted phenoxy, carbonyl-lower alkylamino, N,N-di-lower alkylamino-lower alkylamino, halo substituted lower alkylamino, hydroxy substituted lower alkylamino, lower alkanolyloxy substituted lower alkylamino, ureido, and lower alkoxycarbonylamino; and each X is independently a halogen; or a pharmaceutically acceptable salt thereof, and €ƒ€ƒ€ƒ wherein the (-) stereoisomer is substantially free of the (+) stereoisomer of the compound, in the preparation of a medicament for treating hyperuricemia in a mammal.</p>
申请公布号 CZ20014341(A3) 申请公布日期 2002.11.13
申请号 CZ20010004341 申请日期 2000.06.02
申请人 METABOLEX, INC.;DIATEX, INC. 发明人 LUSKEY KENNETH L.;LUO JIAN
分类号 A61K45/00;A61K31/215;A61K31/216;A61K31/425;A61K31/455;A61K31/64;A61K38/28;A61K45/06;A61P3/04;A61P3/06;A61P3/10;A61P5/48;A61P9/00;A61P9/10;A61P13/12;A61P15/00;A61P19/06;A61P25/02;A61P27/02;(IPC1-7):A61K31/222;A61P13/00 主分类号 A61K45/00
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