Catalytic antibodies which hydrolyze primary amides and methods for eliciting and use of such antibodies

摘要

Described and claimed are compounds of the formulawherein:Y is a polypeptide,R1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C1-21 alkyl, alkene, or alkyne group,R2 is a side chain of a naturally occuring amino acid,and X isSuch compounds are useful as haptens and immunogens for the elicitation of antibodies which catalytically enhance the rate of formation or hydrolysis of primary amide bonds. Also described and claimed are methods employing the compounds and antibodies.