摘要 |
The invention is directed to physiologically active compounds of formula (I):wherein:R1 is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy;X1, X2 and X6 independently represent N or CR10; andone of X3, X4 and X5 represents CR11 and the others independently represents N or CR10;where R10 is hydrogen, amino, halogen, hydroxy, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, nitro or trifluoromethyl; and R11 represents a group -L1-Ar1-L2-Y; and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates of such compounds and their N-oxides and prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4 (alpha4beta1).
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