METHOD OF SYNTHESIS OF 1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4- PHENYLPIPERIDINE-1-YL)-1-PROPANOL MESYLATE TRIHYDRATE AND INTERMEDIATE COMPOUNDS

摘要

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to novel method of synthesis of compound mesylate trihydrate of the formula (I) , (1S,2S)-1- (4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidine-1-yl)-1-propanol, by reduction of carbonyl group of (2S)- compound of the formula (II): where R1 means protective group followed by removal of protective group R1 from reduced compound. Invention relates to novel compounds of the formula (II) and method of their synthesis also. EFFECT: improved methods of synthesis. 19 cl, 1 tbl