| 摘要 |
The invention describes novel nitrosated and/or nitrosylated nebivolol, nove l nitrosated and/or nitrosylated metabolites of nebivolol and novel compositio ns comprising at least one nitrosated and/or nitrosylated nebivolol and/or at least one nitrosated and/or nitrosylated metabolite of nebivolol, and optionally, at least one nitric oxide donor and/or at least one antioxidant or a pharmaceutically acceptable salt thereof, and/or at least one compound use d to treat cardiovascular disease or a pharmaceutically acceptable salt thereo f, and/or at least one nitrosated compound used to treat cardiovascular disease s. The invention also provides novel compositions comprising nebivolol and/or a t least one metabolite of nebivolol and at least one nitric oxide donor, and, optionally, at least one antioxidant or a pharmaceutically acceptable salt thereof, and/or at least one compound used to treat cardiovascular diseases or a pharmaceutically acceptable salt thereof, and/or at least one nitrosated compound used to treat cardiovascular diseases. The compounds and compositio ns of the invention can also be bound to a matrix. The nitric oxide donor is a compound that donates, transfers or releases nitric oxide, elevates endogeno us levels of endothelium-derived relaxing factor, stimulates endogenous synthes is of nitric oxide or is a substrate for nitric oxide synthase and may preferab ly be isosorbide dinitrate and/or isosorbide mononitrate. The antioxidant may preferably be a hydralazine compound or a pharmaceutically acceptable salt thereof. The invention also provides methods for treating and/or preventing vascular diseases characterized by nitric oxide insufficiency; and for treating and/or preventing Raynaud's syndrome; and for treating and/or preventing cardiovascular diseases or disorders.
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