| 摘要 |
The present invention concerns the modulation of glycogene synthase kinase 3beta (G3SK-3beta) by an adenosine receptor ligand. Depending on the type of ligand, the modulation may be manifested by down-regulation or up-regulation of the kinase's activity. Thus, there is provided by the present invention a method and pharmacetical compositions for achieving a therapeutic effect involved in modulating GSK-3beta activity in cells by the use of an adenosine receptor ligand or a combination of ARLs. When modulation involves activation of GSK-3beta activity the ARL may be an adenosine A1 receptor agonist (A1RAg), an adenosine A3 receptor agonist (A3RAg), an adenosine A2 receptor antagonist (A2RAn) or any combination of the same, while when modulation involves inhabition of GSK-3beta activity the ARL may be an adenosine A1 receptor antagonist (A1RAn), an adenosine A3 receptor antagonist (A3RAn), an adenosine A2 receptor agonist (A2RAg) or any combination of the same.
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