ANTIBODIES ABOLISH PRION PROPAGATION AND PROMOTE CLEARANCE OF INFECTIVITY
摘要
Methods are disclosed whereby formulations of molecules are administered rendering cells resistant to infection with infectious proteins such as prions. The formulation preferably comprises a plurality of Fab fragments which (1) recognize and selectively bind to a range of epitopes on the protein of interest, (e.g. epitopes on PrP<C>) and (2) bind to epitopes which interrupt the chain of events resulting in a change of the protein's conformation to an infectious disease conformation of the protein. The molecules and formulation are also useful in clearing infectious proteins from cells.
申请公布号
WO02087502(A2)
申请公布日期
2002.11.07
申请号
WO2002US13346
申请日期
2002.04.25
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;PRUSINER, STANLEY, B.;PERETZ, DAVID;WILLIAMSON, R., ANTHONY;BURTON, DENNIS, R.
发明人
PRUSINER, STANLEY, B.;PERETZ, DAVID;WILLIAMSON, R., ANTHONY;BURTON, DENNIS, R.