| 摘要 |
The invention provides TBX5 protein fragments that regulate normal and malignant cell growth and nucleic acids encoding these fragments. Such protein fragments include a translated 5' T-box sequence capable of binding to the major groove of target DNA and lack a translated 3' T-box sequence that binds to target DNA's minor groove. In particular, the invention protein fragments that inhibit cell proliferation, this activity requiring T-box interaction with target DNA's major groove, but not target DNA's minor groove.
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