20−HYDROXYEICOSATETRAENOIC ACID PRODUCTION INHIBITORS

摘要

Hydroxyformamidine compounds represented by the following general formula or pharmaceutically acceptable salts thereof: wherein R1 represents substituted morpholino, substituted piperidino, piperazin−1−yl, substituted piperazin−1−yl, thiomorpholin−1−yl, perhydroazepin−1−yl, perhydroazocin−1−yl, tetrahydropyridin−1−yl, pyrrolin−1−yl, etc.; X represents nitrogen or CR5; and R2 to R5 are the same or different and each represents hydrogen, C1−4 alkyl, C1−4 alkoxy, trifluoromethyl or halogeno. Drugs inhibiting 20−HETE synthase relating to contraction/dilation of microvessels, induction of cell proliferation, etc. in main organs such as kidney and cerebral vessels.