MEDICINE FOR INHIBITING DRUG ELIMINATION PUMP

摘要

A medicine for prevention and/or therapy of a microbe infectious disease, which comprises, as an active component, a compound represented by the following formula (1): (1) wherein R1 and R2 each represent hydrogen, a halogen atom, a hydroxyl group or the like; W1 represents -CH=CH-, -CH2O-, - CH2 CH2- or the like; R3represents hydrogen, a halogen atom, a hydroxyl grou p or an amino group; R4represents hydrogen, a group of -OZ0-4R5 (where Z0-4 represents an alkylene group or a fluorine-substituted alkylene group or a single bond and R5 represents a cyclic alkyl group, an aryl group or the lik e) or the like; W2 represents a single bond or -C(R8)=C(R9)- (where R8 and R9 each represent hydrogen, a halogen atom, a lower alkyl group or the like) an d Q represents an acidic group, with the proviso that W2 and Q may together fo rm a heterocyclic ring of vinylidene thiazolidinedione or an equivqlent thereof ; m and n each represent an integer of 0 to 2 and q represents an integer of 0 to 3.