IMPROVED LYSOSOMAL ENZYMES AND LYSOSOMAL ENZYME ACTIVATORS
摘要
A polypeptide selected from the group of lysosomal enzymes and lysosomal enzyme activators, comprising at least one introduced glycosylation site as compared to a corresponding parent enzyme or activator. By introducing additional glycosylation sites the resulting glycosylated lysosomal enzyme or activator obtains improved in vivo activity and thereby provides for improved treatment of lysosomal storage diseases.
申请公布号
WO0149830(A9)
申请公布日期
2002.11.07
申请号
WO2000DK00743
申请日期
2000.12.29
申请人
MAXYGEN APS
发明人
OKKELS, JENS, SIGURD;JENSEN, ANNE, DAM;HALKIER, TORBEN;JENSEN, RIKKE, BOLDING;SCHAMBYE, HANS, THALSGAARD