发明名称 |
Novel TNF receptor death domain ligand proteins and inhibitors of ligand binding |
摘要 |
Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed. |
申请公布号 |
US2002164716(A1) |
申请公布日期 |
2002.11.07 |
申请号 |
US20010989350 |
申请日期 |
2001.11.20 |
申请人 |
LIN LIH-LING;CHEN JENNIFER;SCHIEVELLA ANDREA R.;GRAHAM JAMES |
发明人 |
LIN LIH-LING;CHEN JENNIFER;SCHIEVELLA ANDREA R.;GRAHAM JAMES |
分类号 |
A61K38/00;C07K14/47;C07K16/24;C12N15/12;(IPC1-7):C12Q1/68;C07H21/04;C12P21/02;C12N5/06;C07K14/52 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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