| 摘要 |
<p>Spiropiperidine derivatives typified by compounds represented by the general formula [I]: [I] wherein the ring A, D, R1, R3a, R3b, R4, R5a, R5b, R6, R7, R8, Ar, Y1, Y2, Y3, Y4, m1, n and x are each as defined in the description. These compounds have an antagonistic effect on the binding of nociceptin to a nociceptin receptor ORL1 at an extremely low concentration, which makes them useful as analgesics for cancer pain and diseases in associated with pain, antagonists to narcotic analgesic-tolerance, antagonists to narcotic analgesic-addiction or withdrawal syndrome, analgesic potentiators, antiobestics, brain function improving agents, remedies for Alzheimer’s disease, remedies for dementia, remedies for schizophrenia, remedies for degenerative neurodegenerative diseases, antidepressants, remedies for diabetes insipidus, remedies for polyuria and remedies for hypotension.</p> |
