摘要 |
The present invention relates to a process for deriving dendritic cells from mononuclear cells in culture comprising the step of putting in contact type I IFN with said mononuclear cells. Dendritic cells suitable as cellular adjuvants in prophylactic as well as therapeutic vaccination of animal and human beings, are obtainable thereby, after a single step treatment in a brief period of time. Dendritic cells obtainable thereby, pharmaceutical compositions including them, in particular a vaccine comprising said cells as active principle, and a method of treatment of a pathology associated with the presence of an antigen in human beings, are further objects of the invention, as well as a kit for deriving said dendritic cells and a method for the ex vivo expansion of T cells using them. |
申请人 |
ISTITUTO SUPERIORE DI SANITA;BELARDELLI, FILIPPO;SANTINI, STEFANO, MARIA;PARLATO, STEFANIA;DI PUCCHIO, TIZIANA;LOGOZZI, MARIANTONIA;LA PENTA, CATERINA;FERRANTINI, MARIA;SANTODONATO, LAURA;D'AGOSTINO, GIUSEPPINA |
发明人 |
BELARDELLI, FILIPPO;SANTINI, STEFANO, MARIA;PARLATO, STEFANIA;DI PUCCHIO, TIZIANA;LOGOZZI, MARIANTONIA;LA PENTA, CATERINA;FERRANTINI, MARIA;SANTODONATO, LAURA;D'AGOSTINO, GIUSEPPINA |