发明名称 |
Methods and compounds for prevention of graft rejection |
摘要 |
Disclosed is a method of localized immunosuppression which may be used for preventing graft rejection or for preventing tissue destruction due to autoimmune disease. Also disclosed is a protein suppressor factor that is secreted by cloned anergic T-cells, blocks interleukin 2 (IL-2) stimulated T-cell proliferation, has an apparent molecular weight of between 10 and 30 kilodaltons, can be inactivated by heating to 65° C. for 15 minutes, blocks interleukin 4 (IL-4) stimulated T-cell proliferation in vitro, is non-cytotoxic to T-cells, and does not inhibit the production of IL-2 by T-cells in vitro.
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申请公布号 |
US2002164311(A1) |
申请公布日期 |
2002.11.07 |
申请号 |
US20010804717 |
申请日期 |
2001.03.12 |
申请人 |
BETH ISRAEL HOSPITAL ASSOCIATION, A MASSACHUSETTS CORPORATION |
发明人 |
STORM TERRY B.;LIBERMANN TOWIA |
分类号 |
A61K38/00;A61K48/00;A61P37/06;C07K14/47;C07K14/495;C07K14/54;(IPC1-7):A61K48/00;C12N15/87 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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