| 发明名称 |
Preparation of a camptothecin derivative by intramolecular cyclisation |
| 摘要 |
<p>The present invention relates to a method for preparing intermediates useful in the preparation of camptothecin and camptothecin-like compounds and to the intermediates used in this preparation. In particular, the invention provides a process for the preparation of a compound of formula II' <CHEM> wherein X is halogen, which comprises reacting a compound of formula III <CHEM> with a compound of formula IX' <CHEM></p> |
| 申请公布号 |
EP1254908(A1) |
申请公布日期 |
2002.11.06 |
| 申请号 |
EP20020014439 |
申请日期 |
1995.05.02 |
| 申请人 |
GILEAD SCIENCES, INC.;NORTH CAROLINA STATE UNIVERSITY |
发明人 |
FANG, FRANCIS, GERARD;HUIE, EDWARD, MCDONALD;XIE, SHIPING;COMINS, DANIEL, L |
| 分类号 |
A61P35/00;A62D3/00;A61K31/495;B01J31/28;C07B61/00;C07D491/04;C07D213/64;C07D213/69;C07D213/71;C07D491/052;C07D491/056;C07D491/22;C07D519/00;(IPC1-7):C07D519/00 |
主分类号 |
A61P35/00 |
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