METHOD OF DETECTING LIGAND OR LIGAND-LIKE LOW-MOLECULAR WEIGHT COMPOUND

摘要

A method of detecting a ligand or a ligand-like low-molecular weight compound from among test compounds characterized by separating a ligand-dependent cell line having a ligand receptor gene and an antibiotic resistance gene transferred thereinto from other cell lines, culturing the cell line in the presence of the test compounds and then examining the proliferation ability of the cells. Use of this method makes it possible to exactly screen a ligand (a physiologically active substance) or a low-molecular weight compound having the same action by a simple procedure.