PURPOSE: Provided is a method for economically synthesizing glibenclamide, with powder shape, which is used as an intermediate for synthesis of medicine useful for treatment of diabetes. CONSTITUTION: The method comprises the steps of (i) reacting N-phenethyl-5-chloro-2-methoxybenzamide with chlorosulfonic acid(ClSO3H) represented by formula 2 in the presence of thionyl chloride(SOCl2) to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfonylchloride represented by formula 3; (ii) reacting sulfonylchloride compound represented by formula 3 with ammonia to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfoneamide represented by formula 4; (iii) reacting sulfoneamide compound represented by formula with alkali metal hydroxide in the presence of alcohol solvent to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfone amide-metal salt represented by formula 5; and (iv) reacting the metal represented by formula 5 with cyclohexyl isocyanate or phenylcyclohexyl carbamate to form glibenclamide represented by formula 1.
申请公布号
KR20020083568(A)
申请公布日期
2002.11.04
申请号
KR20010022944
申请日期
2001.04.27
申请人
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
发明人
HWANG, UI HYEONG;JANG, HAE SEONG;JUNG, GEUN HOE;KIM, DAE HWANG;KIM, SEON OK;KO, YEONG GWAN;KOO, DONG WAN;RYU, JAE UK;WOO, JAE CHUN